Microbial metabolism of anthracycline antibiotics daunomycin and adriamycin.

Mammary tumors induced in rats by adriamycin and daunomycin.

The two anthracycline antitumor antibiotics, Adriamycin and daunomycin (DM), induced a high incidence of mammary tumors, both fibroadenomas and adenocarcinomas, in female rats that received a single i.v. dose, thus confirming previous results. The incidence of DM-induced adenocarcinomas increased with the dose of the drug, whereas the incidence of Adriamycin-induced adenocarcinomas showed a pla...

Structure-activity relationship of anthracycline-induced genotoxicity in vitro.

Anthracycline antitumor antibiotics, such as Adriamycin and daunomycin, are potent genotoxic agents and carcinogens. A variety of anthracycline derivatives was investigated in various in vitro short-term tests, i.e., mutagenesis in Salmonella typhimurium and V79 Chinese hamster cells and induction of unscheduled DNA synthesis in primary rat hepatocytes. Compounds containing a daunosamine sugar ...

Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.

The anticancer drugs adriamycin and daunomycin have each been crystallized with the DNA sequence d(CGATCG) and the three-dimensional structures of the complexes solved at 1.7- and 1.5-A resolution, respectively. These antitumor drugs have significantly different clinical properties, yet they differ chemically by only the additional hydroxyl at C14 of adriamycin. In these complexes the chromopho...

Lethal effect of adriamycin on the division cycle of HeLa cells.

Adriamycin, a new antitumor antibiotic in the anthracycline group, promptly inhibits DNA and RNA synthesis and arrests cell division. The cell viability (defined as the capacity of a single cell to grow out into a macroscopic clone) is reduced sharply following exposure to adriamycin, 0.1 fig/ml, for a fractional period of the generation time. With the use of a synchronous population of HeLa ce...

SYNTHESIS OF 4-DEMETHOXY-II- DEOXY-ANALOGS OF DAUNOMYCIN AND ADRIAMYCIN Sir: In our study of new anthracycline analogues, after modification of the sugar moiety